CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, de Agüero MG, Szalay A, Lämmermann T, Macpherson AJ, Ganal-Vonarburg SC, Backofen R, Erny D, Prinz M, Blank T.

Nat Neurosci. 2022; doi: 10.1038/s41593-022-01027-3

We found that the microbiota influenced aging associated-changes in microglial gene expression. This study adds insight into how specific features of microglia from aged mice are regulated by the gut microbiota.