CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery

Busto JV, Ganesan I, Mathar H, Steiert C, Schneider EF, Straub SP, Ellenrieder L, Song J, Stiller SB, Lübbert P, Chatterjee R, Elsaesser J, Melchionda L, Schug C, den Brave F, Schulte U, Klecker T, Kraft C, Fakler B, Becker T, Wiedemann N

Cell Rep. 2024; doi: 10.1016/j.celrep.2024.113805.

We demonstrate that the alpha-helical outer membrane protein Mco6 co-assembles with the mitochondrial distribution and morphology protein Mdm10 as part of the sorting and assembly machinery/SAM. This work uncovers a role of the SAMMco6 complex for the biogenesis of the mitochondrial outer membrane.