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A prize for the CIBSS spirit

First InteGREATor award for excellent publications in integrative signalling science goes to Dr. Maximillian Hörner, Nadim Aizarani and Jelena Tosic

CIBSS is committed to supporting scientists in pursuing research on an integrative level: Across scales in living organisms, across research fields and from early on in their career. To bring forward the integrative aspects of the work of early career CIBSS researchers and to value their publication effort, CIBSS created the InteGREATor award. It will be granted to postdoctoral researchers and doctoral students at CIBSS for their most outstanding publications that fall into the research spectrum of the cluster of excellence.

The winners are awarded € 3.000 for postdocs € 2.000 for doctoral researchers – money that can be spent for their research inside the cluster. All three awardees were first authors of the studies they published.

Optogenetics, Single Cell Biology and Embryology: In three different disciplines these publications display the ideas and goals of CIBSS. The implemantation of the cluster’s program is taking form: It brings forward first class research results through an integrative and interdisciplinary perspective, that allows for a wider, more holistic view of how signals steer an organism.

The research program of CIBSS is well represented in the selected publications of the awardees: They cover mechanistic understandings of organizational signals on the single cell level up to organs as in the case of the liver by Nadim Aizarani or of cell fate in development by Jelena Tosic. Additionally, Dr. Maximillian Hörner receives the post-doctoral award for the development of his tunable hydrogel controlled by light – a control-of-function technology and another focus inside the CIBSS research program.

Awardees

Dr. Maximilian Hörner is a junior group leader at the lab of Prof. Wilfried Weber at the University of Freiburg. With his research, he covers new ground in the area of extracellular optogenetics and created a hydrogel whose stiffness and permeability to cells can be controlled with light “It is a prime example of how the different disciplines in CIBSS can contribute to one joint aim.”, says the committee. The involved disciplines and methods included synthetic biology, immunology, RNA-sequencing, atomic force microscopy and mathematical modelling.

Find out more about this study: https://www.cibss.uni-freiburg.de/news/weber-hydrogel-2019

Title of the publication in Advanced Materials:

Phytochrome-based extracellular matrix with reversibly tunable mechanical properties

Nadim Aizarani is a doctoral researcher at the lab of Prof. Dominic Grün at the Max Planck Institute for Immunobiology and Epigenetics. “His impressive work based on single cell resolution of the liver, delivers a comprehensive liver atlas, and he provides a powerful resource for investigating cell types in normal and diseased livers”, the committee stated. His research serves CIBSS’ integrative vision by enabling researchers to better understand the signalling processes as well as communication networks within and between liver cell types.

Find out more about this study: https://human-liver-cell-atlas.ie-freiburg.mpg.de/

Title of the publication in Nature:

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Jelena Tosic performed her doctoral research at the lab of CIBSS Member Prof. Sebastian Arnold at the University of Freiburg. “She has published an outstanding article on developmental biology, in which her work sheds light on the control mechanisms that guide the first cell lineage decision during germ layer formation in mammals”, the committee stated. Her work is embedded into an interdisciplinary CIBSS research team. “The research topic fits perfectly into CIBSS’ vision by analysing biological processes across different scales”, the committee further added. She received her PhD in 2019 following the publication and continues to work in the lab of Sebastian Arnold as a postdoctoral researcher.

Find out more about this study: https://www.cibss.uni-freiburg.de/news/arnold-stammzellen-2019

Title of the publication in Nature Cell Biology:

Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state