CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Mitochondrial perturbations couple mTORC2 to autophagy in C. elegans

Aspernig H, Heimbucher T, Qi W, Gangurde D, Curic S, Yan Y, Donner von Gromoff E, Baumeister R, Thien A.

Cell Rep. 2019;29(6):1399-1409.

Cell Rep.                  online article

The multiprotein complex mTORC2 is a central regulator of development and metabolism. Aspernig et al. implicate C. elegans mTORC2 and its effector SGK- 1 in mitochondrial homeostasis and report that an increased release of mitochondria-derived reactive oxygen species induces autophagy in mTORC2/ SGK-1-deficient animals.