CIBSS - Centre for integrative Biological Signalling Studies CIBSS

IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread

Hinz F, Friedel D, Korshunov A, Ippen F M, Bogumil H, Banan R, Brandner S, Hasselblatt M, Boldt H B, Dirse V, Dohmen H, Aronica E, Brodhun M, Broekman M L D, Capper D, Cherkezov A, Deng M Y, van Dis V, Felsberg J, Frank S, French PJ, Gerlach R, Göbel K, Goold E, Hench J, Kantelhardt S, Kohlhof-Meinecke P, Krieg S, Mawrin C, Morrison G, Mühlebner A, Ozduman K, Pfister S M, Poliani P L, Prinz M, Reifenberger G, Riemenschneider M J, Sankowski R, Schrimpf D, Sill M, Snuderl M, Verdijk R M, Voisin M R, Wesseling P, Wick W, Reuss D E, von Deimling A, Sahm F, Maas S L N, Suwala A K.

Acta Neuropathol. 2025; doi: 10.1007/s00401-025-02849-8.

ASTRO PNC is defined by a distinct molecular and histological appearance that can mimic metastatic disease and typically follows an aggressive clinical course.